Supports gut barrier health


Benefits and Features

  • Helps protect your stomach and small intestine lining.
  • Promotes digestive comfort.

Detail Overview

Zinc carnosine has been shown in multiple clinical trials to help protect the stomach lining and promote gastrointestinal comfort. Studies show zinc carnosine promotes healthy mucus secretion, exerts antioxidant properties, and modulates cytokine expression, thus helping protect the stomach and small intestine. L-glutamine promotes small intestinal cell function and mucosal integrity to further support gastric function and protect tissues. 


This patented, 1:1 chelate of zinc and l-carnosine provides a unique configuration that accounts for this compound's unique functions in the GI tract. Zinc-carnosine has a slow dissociation rate and adheres to the stomach lining, allowing for prolonged protection.1 When zinc and carnosine are separated, they provide synergistic antioxidant protection, support the stomach's mucosal defenses, buffer gastric acid, and maintain healthy cytokine release.2 According to studies, this combination is more effective than either ingredient alone in maintaining the integrity of the gastric lining.3 A Japanese multi-center, double-blind study involving 299 subjects found improvements in objective and subjective parameters of normal gastric health and repair, particularly after 8 weeks of daily supplementation.4 Seven additional clinical trials involving over 550 volunteers yielded similar results. In vitro and in vivo studies show that zinc-carnosine promotes cellular repair in the intestine by promoting healthy cell reproduction and villous function.5 Zinc-carnosine maintained healthy gut barrier function in a double-blind, randomized, crossover trial.6 This zinc-carnosine combination has been extensively researched and used in Japan, and it has an excellent safety profile. 


1. Arakawa T, et al. Dig Dis Sci. 1990 May;35(5):559-66. 

2. Shimada T, et al. J Pharmacol Exp Ther. 1999 Oct;291(1):345-52. 

3. Sakae K, et al. Nutr Clin Pract. 2013 Oct;28(5):609-16. 

4. Miyoshi A, et al. Jpn Pharmacol Ther. 1992. 20;20(1):199?223. 

5. Watanabe S, et al. Aliment Pharmacol Ther. 1998 Nov;12(11):1131-8. 

6. Mahmood A, et al. Gut. 2007 Feb;56(2):168-75. 

Serving Size 1 Capsule
Amount Per Capsule % Daily Value
Zinc (as zinc L-carnosine complex) 17 mg 155%
Zinc L- Carnosine Complex 83 mg *
L-Glutamine 400 mg *
* Daily value not established

Other Ingredients:

Vegetarian capsule (hydroxypropyl methylcellulose, water), ascorbyl palmitate, and microcrystalline cellulose.

References: undefined

pepZinGI® brand, a registered trademark of Hamari Chemicals, Ltd.

Suggested Use

Adults: 1 capsule twice daily or as directed by a healthcare professional. Children: As directed by a healthcare professional.

Allergy Statement

Made without the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, soybeans, corn, yeast, and sesame. No synthetic colors or flavors. Vegan and Non-GMO.


Consult with your physician if you are pregnant, nursing, have a medical condition, taking prescription drugs, or are under the age of 18 years. KEEP OUT OF REACH OF CHILDREN.