The Entourage Effect: Synergy Explained

The Entourage Effect: Synergy Explained

Our bodies are composed of trillions of microbes-viruses, bacteria, fungi, etc.-that collectively constitute our microbiome. These microorganisms coexist and interact with our own cells, exerting significant influence on several essential functions throughout the human body, from immunity and nutrient absorption to the direct mediation of neurotransmitters and hormones. ^{1, 2}

Because of the connection between the microbiome and other, seemingly independent, body functions, modifications to existing intestinal microflora via probiotics have been clinically demonstrated to beneficially impact digestion, immune function, mood and behavior balance, and healthy inflammation levels, where inflammation is associated with occasional digestive discomfort.³

Probiotics, when supplemented alone, can both promote and assist in the maintenance of a healthy GI environment, thereby supporting numerous beneficial actions throughout the body.^† But, as evidence continues to emerge concerning the vital role of fiber in optimal microbiome function, practitioners who recommend probiotics are also now turning to probiotics’ less popular, but very powerful, counterpart: prebiotics.

Prebiotics are non-digestible carbohydrates that serve as food for probiotics. Typically found in high-fiber foods such as whole grains, bananas, greens, onions, garlic, soybeans, and artichokes, prebiotics are necessary for probiotics to grow and multiply.

While it is possible to supplement with two separate products–a prebiotic and a probiotic–it might be more effective, and ultimately more convenient, to explore the benefits of the next generation of microbiome-supporting products: synbiotics.^† The name “synbiotic”-a fusion of “synergy” and “biotic”-loosely translates to “working better together to promote life.” As this unique nomenclature suggests, synbiotics contain a synergistic combination of live bacteria and prebiotics that provides the gut with the nutrients it needs to support whole-body wellness.^†

Better Together

The fundamental purpose of synbiotics is simple: feeding friendly bacteria at the moment of supplementation creates, within the GI tract, a more profound “entourage” effect-a phenomenon that occurs where two or more substances create a unique third action or signal.⁴ When probiotics and prebiotics are delivered concomitantly, not only can a magnified improvement effect result from the enhanced survival and adhesion of the probiotics but also a more profound metabolic impact that may lead to health-supporting outcomes.^{† 2, 3}

Synbiotics are available in supplement and in food forms, both of which can be used to support overall health by boosting probiotic populations in the gut.^† When considering synbiotic options, it’s important to seek a high-quality supplement offered by an established and reputable brand. Be sure to verify that the product has been developed using clinically demonstrated, live probiotic strains, at scientifically researched amounts, and that nutritious, plant-based sources of prebiotics are included. 

The human microbiome is more complex than previously thought, wielding a colossal impact on whole-body health and wellness.^† Maintaining a healthy gut contributes to a strong immune system and supports heart health, brain health, healthy sleep, effective digestion, and mood balance.^† But, there is no one-size-fits-all when it comes to the health of your microbiome. Consult with your healthcare practitioner to see if a synbiotic is right for you.