Download as PDF

Berberine is a bioactive compound found in several plants, including goldenseal, barberry, and Oregon grape. It has been used in traditional medicine for centuries and has gained popularity as a dietary supplement due to its health benefits. Here are some research-backed benefits of supplementing with berberine:

  1. Blood sugar control: Berberine may help improve blood sugar control by reducing insulin resistance and increasing glucose uptake by cells. A systematic review and meta-analysis of 14 randomized controlled trials found that berberine significantly decreased fasting blood glucose levels in people with type 2 diabetes mellitus.1

  2. Cholesterol-lowering effects: Berberine may help reduce cholesterol levels by inhibiting an enzyme called HMG-CoA reductase, which is involved in cholesterol synthesis. A systematic review and meta-analysis of 24 randomized controlled trials found that berberine significantly reduced total cholesterol, LDL-cholesterol, and triglyceride levels in people with hyperlipidemia.2

  3. Anti-inflammatory effects: Berberine may have anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines. A systematic review and meta-analysis of 12 randomized controlled trials found that berberine significantly reduced levels of C-reactive protein (CRP), a marker of inflammation, in people with metabolic syndrome.3

  4. Gut health: Berberine may help promote a healthy gut microbiome by altering the composition of gut bacteria. A randomized controlled trial found that berberine supplementation increased the abundance of beneficial bacteria, such as Bifidobacterium and Lactobacillus, and decreased the abundance of harmful bacteria, such as Clostridium difficile, in people with diarrhea-predominant irritable bowel syndrome.4

  5. Weight management: Berberine may help promote weight loss by reducing body weight and body mass index (BMI). A systematic review and meta-analysis of 11 randomized controlled trials found that berberine significantly decreased body weight and BMI in people with overweight or obesity.5

Overall, while more research is needed to fully understand the potential health benefits of berberine, these studies suggest that it may have a positive impact on blood sugar control, cholesterol levels, inflammation, gut health, and weight management. It is important to note that supplementing with berberine may cause side effects and interact with certain medications, so it is recommended to consult with a healthcare professional before taking it.